Steve McClaren will have right-back Daryl Janmaat available for the home clash against Arsenal, with the Dutch international returning from a one-match ban.
That means Chancel Mbemba and Steven Taylor will be battling it out to partner Fabricio Coloccini at the heart of the defence, with Massadio Haidara lining up at left-back. Jack Colback and Vurnon Anita should continue at the base of midfield in the 4-2-3-1 system favoured by the former England boss.
Moussa Sissoko has returned to training but is set for a last-minute fitness test – if he misses out, new signing Florian Thauvin could be handed his first league start on the right of the three attacking midfield positions after scoring one goal and providing three assists in the 4-1 Capital One Cup win against Northampton Town on Tuesday.
Georginio Wijnaldum and Ayoze Perez look the other likely starters, with Gabriel Obertan making way.
Siem de Jong and Rolando Aarons are other options available for McClaren, while Aleksandar Mitrovic is expected to keep his place as the lone striker ahead of Papiss Cisse. The latter has recovered from the illness that kept him out of the midweek cup match.
Emmanuel Riviere is Newcastle’s only long-term absentee, but Paul Dummett is now available for selection after recovering from a hamstring problem.